Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice
نویسندگان
چکیده
منابع مشابه
Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice
L-type bovine spongiform encephalopathy (L-BSE) is an atypical form of BSE that is transmissible to cattle and several lines of prion protein (PrP) transgenic mice, but not to wild-type mice. In this study, we examined the transmissibility of sheep-passaged L-BSE prions to wild-type mice. Disease-associated prion protein (PrP(Sc)) was detected in the brain and/or lymphoid tissues during the lif...
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Two distinct forms of atypical bovine spongiform encephalopathies (H-BSE and L-BSE) can be distinguished from classical (C-) BSE found in cattle based on biochemical signatures of disease-associated prion protein (PrPSc). H-BSE is transmissible to wild-type mice-with infected mice showing a long survival period that is close to their normal lifespan-but not to hamsters. Therefore, rodent-adapte...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2015
ISSN: 1297-9716
DOI: 10.1186/s13567-015-0211-2